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MCL-1 antibody

MCL-1 antibody
MCL-1 antibody

Background Information:Mcl1 is an anti-apoptotic member of Bcl2 family originally isolated from the ML1 human myeloid leukemia
cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Mcl1 localizes to the mitochondria, interacts
with and antagonizes pro-apoptotic Bcl2 family members, and inhibits apoptosis by a number of cytotoxic stimuli. It is involved in programing
of differentiation and concomitant maintenance of viability but not of proliferation. Isoform 1 inhibits apoptosis while isoform 2 promotes it.
Expression increases early during phorbol-ester induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines
ML1
KeyApplications:
WB=1:100-500
ELISA=1:500-1000
IP=1:20-100
IHC-P=1:100-500
IHC-F=1:100-500
IF=1:100-500

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